The demand for anti-rheumatic drugs is growing due to the rising incidence of rheumatic diseases. A disease refers to any disorder affecting joints, tendons, ligaments…
The heart that sits in our chest cavity is an extremely hardworking muscular organ. It pumps pure oxygenated blood to every part of our body. It has its own blood supply called the coronary circulation. Coronary circulation supplies oxygenated blood to the heart. It comprises of coronary arteries which lie on the outer surface of the heart. What will happen if my arteries get clogged? And why will they get clogged? Coronary artery disease is the clogging of arteries. It occurs mainly due to plaque build-up in the artery. The flow of the blood gets reduced when it flows through the clogged arteries.
How to Win the Battle Against Coronary Artery Disease
For a healthy person by simply cutting out the sugar, processed food, drinking lots of water and by doing regular physical exercise coronary artery disease can be prevented. But what about the people suffering from coronary artery disease? Coronary artery disease involves lifestyle changes, necessary drugs and certain medical procedures. Medical procedures include insertion of metal or plastic tubes into the coronary artery. In medical procedures, a tiny tube made of metal or plastic is inserted into the coronary artery.
Developments in Stenting Procedure
The original procedure of balloon inflation only had its own limitations. However, with the introduction of Bare Metal Stent (BMS) reduced the chances of re-narrowing of the stented blood vessels have decreased. Bare Metal Stent still has serious limitations as a process called neointimal hyperplasia clogs the lumen of the treated coronary artery from inside and leads to re-narrowing also known as re-stenosis. Drug-eluting stents (DES) solves the problem of in-stent restenosis occurs due to the use of bare-metal stents. The first two drug-induced stents were Taxus and Cypher which not only reduced the chances of in-stent renarrowing but also the repeated need of doing the procedure. DES mainly consists of three components- The stent backbone, the Drug and bonding mechanism of the drug to the stent.
Newer Generation DES has Brought New Hope
Newer generation DES has an edge over first-generation DES in patients undergoing primary cutaneous intervention in terms of both efficacy and safety including the better result in long-term follow-up. Currently, ECS recommends in patients, undergoing PCI with modern DES a minimum duration of dual antiplatelet theory. The recent LEADERFREE trial has brought a new dimension in the polymer-free BioFReedom stent. In modern DES a long term clinical data will be required to see if these are really better than BMS. We expect to get a clear picture in the coming years.